Edward Holmes may refer to:
Edward Holmes (architect) (1832–1909), English architect Edward Holmes (field hockey) (1880–1924), Irish field hockey player and Olympic medallist Edward Holmes (musicologist) (1797–1859), English musicologist and music critic Edward Holmes (rugby) (1862–1932), English rugby union player and referee Edward Lorenzo Holmes (1828–1900), American ophthalmologist Edward C. Holmes (born 1965), British evolutionary biologist and virologist Edward Carleton Holmes (1843–1932), one of the solicitors who drew up the first rules of Rugby Football Union Edward Morell Holmes (1843–1930), British botanist, curator and lecturer Lefty Holmes (nicknamed Eddie; 1907–1987), American baseball pitcher
See also Edward Holmes Baldock (1812–1875), British Conservative Party politician Ed Holmes, founder of Saint Stupid's Day Parade