Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.
Expression Based on human and mouse EST profiles and a human tissue GEO profile, TMEM175 appears to be expressed at a relatively high level (75-98%) in normal tissues.EST Profile Viewer- HumanEST Profile Viewer- Mouse TMEM175 appears to be down regulated in stage three ovarian cancer.[
Homology Transmembrane protein 175 has no paralogs. It does have orthologs within eukaryotes. The following table presents some of the orthologs found using searches in BLASTNCBI BLAST: Basic Local Alignment Search Tool and BLAT.BLAT Search Genome This list does not contain all of the orthologs for TMEM175. It is meant to display the diversity of species for which orthologs are found.
Scientific name Common name Accession number Sequence length Percent identity Percent Similarity Homo Sapiens Human NP_115702.1 504 - - Pan troglodytes Chimp XP_001141076 504 92 93 Pongo abelii Orangutan XP_002814537 231 99 99 Macaca mulatta Rhesus XP_001085173.1 403 96 98 Callithrix jacchus Marmoset XP_002746113.1 472 83 87 Bos taurus Cow NP_001069081.1 479 77 82 Ailuropoda melanoleuca Panda XP_002924455.1 498 81 87 Equus caballus Horse XP_001488271.1 499 81 86 Rattus norvegicus Rat NP_001014013.1 499 82 88 Mus musculus Mouse NP_082499.3 499 81 88 Monodelphis domestica Opossum XP_001377424.1 502 67 80 Ornithorhynchus anatinus Platypus XP_001514176 499 68 82 Gallus gallus Chicken NP_001006582.1 501 64 78 Sceloporus occidentalis Lizard - 417 56 66 Taeniopygia guttata Zebra Finch XP_002187908.1 496 66 79 Danio rerio Zebra Fish NP_001093545.1 520 62 76 Branchiostoma floridae Lancelet XP_002596272 409 31 50 Ciona intestinalis Sea Squirt XP_002122718 494 27 50 Nematostella vectensis Starlet Sea Anemone XP_001630719 489 28 49
Predicted Post-Translational Modification Using various tools at ExPASyExPASy Proteomics Server the following are possible post-translational modifications for TMEM175. 5 possible CK2 phosphorylation sites 2 possible PKC phosphorylation sites N-myristoylation sites around transmembrane regions The N-myristoylation sites are conserved in vertebrates.
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Further reading