The year 1503 in science and technology included many events, some of which are listed below.
Astronomy July 23 – Unknown at this time, Pluto moves outside Neptune's orbit, remaining there for 233 years.
Exploration May 10 – Christopher Columbus first sights the Cayman Islands, which he names Las Tortugas after the numerous sea turtles there.
Technology April 21 – Battle of Cerignola: Spanish forces defeat the French, considered the first battle in history won by gunpowder small arms. Giuliano da Sangallo constructs the city waIls of Arezzo in Tuscany using the new technology of bastions.
Births December 14 – Nostradamus, French physician and astrologer (died 1566)
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