Facio is a surname. Notable people with the surname include:
Alda Facio (born 1948), Costa Rican jurist, writer, and teacher Bartolomeo Facio, Italian historian, writer, and humanist Giannina Facio (born 1955), Costa Rican actress and producer Lorena Clare Facio (1943–2026), First Lady of Costa Rica Sara Facio (1932–2024), Argentine photographer
See also Faccio Fatio