Wirthlin is a Swiss surname. Notable people with the surname include:
Joseph B. Wirthlin (1917–2008), American businessman and member of the Quorum of the Twelve Apostles of The LDS Church Joseph L. Wirthlin (1893–1963), the eighth presiding bishop of The LDS Church LeRoy S. Wirthlin (born 1935), professor at Harvard Medical School and later a practicing surgeon Richard Wirthlin (1931–2011), prominent American pollster, Ronald Reagan's chief strategist
See also Wirthlin Worldwide, political and business consulting firm founded by Richard Wirthlin in 1969