Cassirer is a surname of Yiddish origin (קאַסירער kasirer, which means Cashier; ). Notable people with the surname include:

Wilfred Cass, born Wolfgang Cassirer (1924–2022), German-Jewish founder of Cass Sculpture Foundation Bruno Cassirer (1872–1941), German-Jewish publisher and gallery owner in Berlin Ernst Cassirer (1874–1945), German-Jewish philosopher Fritz Cassirer (1871–1926), German-Jewish conductor Heinz Cassirer (1903–1979), German-Jewish philosopher Julius Cassirer (1841–1924), German-Jewish industrialist and art collector Paul Cassirer (1871–1926), German-Jewish art dealer and editor Richard Cassirer (1868–1925), German-Jewish neurologist

See also Jerome P. Kassirer (born 1932), American nephrologist

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