M86 or M-86 may refer to:
Ships HMAS Diamantina (M 86), a Huon-class minehunter in the Royal Australian Navy INS Malpe (M86), an Indian Naval minesweeper ship
Transportation M86 (Johannesburg), a short metropolitan route in South Africa M86 (New York City bus), a bus route in Manhattan, U.S. M86 expressway (Hungary) M-86 (Michigan highway), U.S. M-86-Prairie River Bridge, now the Crystal Springs Street–Dowagiac River Bridge, near Sumnerville, Michigan, U.S.
Weapons and munitions M86 pursuit deterrent munition, a U.S. anti-personnel landmine M86 sniper rifle, a 7.62mm sniper rifle employed by the U.S. military Valmet Sniper M86, a Finnish sniper rifle Zastava M86, a variant of the Zastava M84 machine gun
Other uses M86 Security, an American Internet threat protection company M86 Swimming Center, Madrid, Spain Messier 86, or M86, a lenticular galaxy in the Virgo Cluster Tumansky M-86, a variant of the Gnome-Rhône Mistral Major aircraft engine