The year 1527 in science and technology included a number of events, some of which are listed here.
Mathematics Petrus Apianus publishes a handbook of commercial arithmetic, Ein newe und wolgegründete underweisung aller Kauffmanns Rechnung in dreyen Büchern, mit schönen Regeln und fragstücken begriffen, at Ingolstadt.Depicted in Holbein's painting The Ambassadors (1533) –
Military science Albrecht Dürer publishes a treatise on fortifications, , in Nuremberg.
Births c. May 1 – Jan Van Ostaeyen (Johannes Stadius), Flemish mathematician and astronomer (died 1579) July 13 – John Dee, English alchemist, astrologer and mathematician (died 1609)
Deaths January 21 – Juan de Grijalva, Spanish explorer (born c. 1489) July 28 – Rodrigo de Bastidas, Spanish explorer (born c. 1460)
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