Kalpakian or Kalpakyan () is a surname of Armenian origin. Notable people with the surname include:
Arda Kalpakian (born 1944), Lebanese Olympic athlete Laura Kalpakian (born 1945), American author Sebouh Kalpakian (born ?), Lebanese Armenian politician Sirvart Kalpakyan Karamanuk (1912–2008), Armenian composer, pianist