The ISCB Overton Prize is a computational biology prize awarded annually for outstanding accomplishment by a scientist in the early to mid stage of their career. Laureates have made significant contribution to the field of computational biology either through research, education, service, or a combination of the three.

The prize was established by the International Society for Computational Biology (ISCB) in memory of G. Christian Overtonhttp://www.bioinfo.de/isb/2000/01/0021/Chris-Overton.html Dr. G. Christian Overton a major contributor to the field of bioinformatics and member of the ISCB Board of Directors who died unexpectedly in 2000.

The Overton Prize is traditionally awarded at the Intelligent Systems for Molecular Biology (ISMB) conference.

Laureates Laureates of the Overton Prize include: 2025 - The 2025 ISCB Overton Prize Award—Dr James Zou 2024 - Martin Steinegger 2023 - Jingyi Jessica Li 2022 - 2021 - Barbara Engelhardt 2020 - 2019 - Christophe Dessimoz 2018 - Cole Trapnell 2017 - Christoph Bock 2016 - Debora Marks 2015 - Curtis Huttenhower e1004319 2014 - Dana Pe'er e1003682 2013 - Gonçalo Abecasis 2012 - Ziv Bar-Joseph e1002535 2011 - Olga Troyanskaya e1002081 2010 - Steven E. Brenner e1000831 2009 - Trey Ideker | e1000375 2008 - Aviv Regev e1000101 2007 - Eran Segal 2006 - Mathieu Blanchette 2005 - Ewan Birney 2004 - Uri Alon 2003 - Jim Kent 2002 - David Baker 2001 - Christopher Burge

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