Persiani is an Italian surname. Notable people with the surname include:
Fanny Tacchinardi Persiani (1812–1867), an Italian soprano singer. Francesco Persiani (born 1965), an Italian politician. Giuseppe Persiani (1799–1869), an Italian opera composer. Luca Persiani (1984–2024), an Italian racing driver. Mauro Persiani (born 1956), a retired Italian professional football player.