Papalia () is an Italian surname. Notable people with the surname include:
Adam Papalia, Australian sportscaster Carmen Papalia (born 1981), Canadian artist The Papalia 'ndrina, an Italian criminal clan Antonio Papalia (born 1954), Italian mobster Domenico Papalia (1945–2026), Italian mobster Melanie Papalia (born 1984), Canadian actress Paul Papalia (born 1962), Australian politician The Papalia crime family, an Italian–Canadian crime family Johnny Papalia (1924–1997), Canadian mobster