Nadkarni is a surname commonly found in the Indian states of Maharashtra, Goa and Karnataka. Notable people with the surname include:
Bapu Nadkarni (1933–2020), Indian cricketer Dayanand S. Nadkarni (1910–2000), Indian politician Jayant Ganpat Nadkarni (1931–2018), Admiral in Indian Navy, 14th Chief of the Naval staff M. G. Nadkarni, Indian mathematician Nalini Nadkarni (born 1954), American ecologist Sucheta Nadkarni (1967–2019), academic in the field of management Sundar Rao Nadkarni, Indian film actor Sushil Nadkarni (born 1976), American cricketer Anuradha Paudwal Alka Nadkarni (born 1954), Indian playback singer