This is a list of fictional characters from DC Comics who are or have been enemies of the Justice League. In chronological order (with issue and date of first appearance).
Silver Age Villain First appearance DescriptionUltra-Humanite Action Comics #13 (June 1939) He was originally the first recurring nemesis to the Golden Age Superman and possibly the first comic book supervillain. Ultra-Humanite went on to battle the Justice Society of America before setting his sights on the Justice League with the Secret Society of Super Villains.Lex Luthor Action Comics #23 (April 1940) Superman's nemesis; when the Man of Steel joined the League, Luthor saw it as a direct challenge to him and formed two Injustice Gangs. Pre-Crisis, he was a mad scientist; Post-Crisis, a corrupt billionaire.Funhouse AliensJustice League of America #7 (November 1961) Aliens that lost a war in a distant solar system 100,000 years ago. Their weapons were taken away, but they sent a probe through the Universe to record all weapons, enabling them to find one that was able to defeat their foes. They placed themselves in suspended animation for 100,000 years. Their ship instead landed on Earth. Assuming human form, they set up a Funhouse in a newly opened fair and abducted people, including Snapper Carr (the Justice League's mascot), to another planet. The League rescues Carr. Green Lantern sends the aliens back into their ship and into another 100,000-year sleep.Joker Batman #1 (Spring 1940) Batman's nemesis; conned Snapper Carr into turning over his key to League headquarters and ambushed the team with the weapons of their greatest foes, fighting the group to a standstill. Later, believing himself to be dying of cancer, the Joker plunged the world into anarchy by enslaving Earth's villains with his Joker venom in the crossover storyline Joker: Last Laugh.Vandal Savage Green Lantern #10 (Winter 1943) A caveman who was exposed to a meteorite that gave him immortality, and who has manipulated history, such as being a Pharaoh in Egypt and assisting the murder of Julius Caesar; he faced Alan Scott and then the Justice Society, becoming a founding member of the Injustice Society of the World, Savage turned his attention to the League in the wake of the former group's retirement. He gathered Clayface, Thorn, Eclipso, and Solomon Grundy against the team during its first year.Solomon Grundy All-American Comics #61 (October 1944) A super-strong zombie risen from a swamp where Cyrus Gold had died many years earlier, who battles Green Lantern and is resistant to his ring due to the wood in his body. A frequent sparring partner to the Justice Society and often drafted in battles with the League, Grundy returned in one of his incarnations with greater intelligence, seeking true immortality by transferring his brain into Amazo's body.Wizard All Star Comics #34 (March 1945) A dangerous magician who learned many spells such as illusions from a Tibetan monk whom he would later murder. He gathered the first two Injustice Societies. A frequent opponent of the Justice Society, the Wizard would lead the Secret Society of Super Villains against the League, switching bodies with them and learning their identities, only to have his memory wiped afterwards. With his memories restored by Despero, he led his fellow villains against Superman for revenge.Per Degaton All Star Comics #35 (June–July 1947) Generally an enemy to the Justice Society, Degaton organized the Crime Syndicate to steal atomic missiles bringing the United States and Russia to near-war. The combined efforts of the Justice League, the Justice Society, and the All-Star Squadron stopped him.Circe Wonder Woman #37 (September–October 1949) A powerful witch who gained her powers from Hecate, the Greek goddess of witchcraft, and who has a talent for transforming humans into beasts. Usually an enemy of Wonder Woman, Circe would come into conflict with the League on several occasions, including during War of the Gods, a bid to claim the Spear of Destiny, and during Amazons Attack!.King Kull Captain Marvel Adventures #125 (October 1951) Ruler of the Submen who ruled Earth until humanity overthrew them thousands of years ago, killing most of them. Kull was a frequent foe to Captain Marvel due to his superhuman strength, advanced technology and desire to wipe out humanity.Brainiac Action Comics #242 (July 1958) One of Superman's greatest enemies, the alien genius Brainiac faces the League on several occasions, such as "Panic in the Sky" and Brainiac 13's Y2K.Getaway Mastermind Detective Comics #259 (November 1958) An enemy of the Martian Manhunter who organized a prison break and led Captain Cold, the Clock King, the Electric Man, the Puppet Master, and Professor Menace against the League.Gorilla Grodd The Flash #106 (May 1959) One of a race of intelligent gorillas with mental powers. Primarily an enemy of the Flash, Grodd would face the League on several occasions, such as when he led the Secret Society of Super Villains, in the crossover event JLApe: Gorilla Warfare!, and when he enslaved the International Ultramarine Corps.Starro Brave and the Bold #28 (February - March 1960) A large alien starfish who creates smaller copies of itself that attach themselves to others and bring them into the thrall of the original. First foe that the League fought as the League.Weapons Master Brave and the Bold #29 (May 1960) A criminal from the 120th century, Xotar went back in time with a cache of weapons to battle the League, believing that the one to defeat them would be invincible and able to battle the Intersolar Police, due to a book written by Wonder Woman which seemed to indicate that he had defeated the League. He was defeated, however (as the book had been damaged where it recorded his defeat), and sent back to his time period. He would later appear again seeking to obtain Green Lantern's power ring and again as a leader of a cult that worshiped the League.Amazo The Brave and the Bold #30 (June 1960) Built by Professor Ivo, Amazo has the powers and equipment of Wonder Woman, Green Lantern, the Flash, the Martian Manhunter, and Aquaman with the ability to copy the powers of any metahumans that it comes into contact with.Professor Ivo The Brave and the Bold #30 (June 1960) Ivo constructed Amazo in pursuit of immortality. Ivo and his creations are responsible for the deaths of Vibe and Commander Steel.Despero Justice League of America #1 (October 1960) The tyrant of Kalanor, Despero was a frequent opponent to the League with his hypnotic abilities. His abilities were upgraded by the Flame of Py'tar.Saturna Justice League of America #2 (December 1960) The Lord of Misrule, Saturna aligns with Simon Magus to conquer Magic-Land.Simon Magus Justice League of America #2 (December 1960) The evil magician Simon Magus, in his bid to conquer Magic-Land, aligns with Lord Saturna and the Troll King to steal scientific devices from Earth to defeat the realm's ruler Merlin. When artificial devices stop working on Earth due to Magus' efforts, the Justice League become involved in Magus' war.Troll King Justice League of America #2 (December 1960) Attempting to overthrow the wizard Merlin, the Troll King aligns with Simon Magus to conquer Magic-Land.Hyathis Justice League of America #3 (February 1961) Ruler of Alstai, Hyathis was at war with three other planets until Kanjar Ro enslaved the League to defeat Hyathis and the other planets once and for all. In the end, the League toppled all of the warlords. She could breathe underwater and control plant life.Kanjar Ro Justice League of America #3 (February 1961) Using his Gamma Gong to enslave the League, Ro, as the despot of Dhor, sought to conquer neighboring planets that he was consistently at war with, threatening to leave all of Earth in a paralyzed state. He would return to face the League many times.Kromm Justice League of America #3 (February 1961) Ruler of the planet Mosteel; deposed by the Justice League.Sayyar Justice League of America #3 (February 1961) Ruler of the planet Llarr; deposed by the Justice League.Hector Hammond Green Lantern #5 (March–April 1961) Primarily an enemy of Green Lantern, Hammond repeatedly fought the League over the years due to a meteor that evolved him, giving him psionic powers, though it left him unable to walk.Phantom Zone Villains Adventure Comics #283 (April 1961) Criminals trapped in a vast prison discovered by Kryptonian scientists where they are able to see and hear within the universe, but generally unable to interact with it. While largely a problem for Superman, prisoners of the Zone have been known to escape and bring Earth's heroes against them.Matter Master The Brave and the Bold #35 (April–May 1961) A Hawkman foe drafted to battle the Justice League alongside other villains on several occasions, the Matter Master would battle the League when he tried to eliminate the Golden Eagle.Doctor Destiny Justice League of America #5 (June 1961) First impersonated Green Lantern using anti-gravity discs to try to capture the League. Later with the Materioptikon, Destiny was able to turn dreams into reality under his will.Sinestro Green Lantern #7 (July–August 1961) Nemesis to Hal Jordan and rogue Green Lantern, Thaal Sinestro would frequently battle the League as a part of various villainous groups, until forming the Sinestro Corps (who used yellow power rings) and going to war with Earth and its flagship team, the Justice League.Amos Fortune Justice League of America #6 (August–September 1961) A frequent sparring partner of the League who is able to manipulate his own luck, Fortune formed the original Royal Flush Gang.Qwsp Aquaman #1 (January–February 1962) A reality-warping imp of the 5th dimension like Mister Mxyzptlk or Bat-Mite, Qwsp was Aquaman's fan and accompanied him. Later, when Aquaman become rougher and more rugged, Qwsp followed suit, in turn becoming a menace.Appellaxians Justice League of America #9 (February 1962) When the heirs to the Appellaxian kingdom fought on Earth to decide who would rule, they inadvertently brought the Justice League together for its first time in order to stop them. They would return on several occasions to enslave the Earth.Demons Three Justice League of America #10 (March 1962) Abnegazar, Ghast, and Rath are three demon brothers who ruled the galaxy one billion years ago until they were banished by the Timeless Ones. They have made repeated attempts to escape since.Felix Faust Justice League of America #10 (March 1962) A centuries-old mage obsessed with power who sold his soul several times and even sold the soul of his son Sebastian Faust, only to be defeated repeatedly by the League.Lord of Time Justice League of America #10 (March 1962) A time traveler from the year 3786 who consistently comes to the present to menace the League hoping to invade their century, now going by the name Epoch.Doctor Light Justice League of America #12 (June 1962) A scientist turned villain, he went on to fight the League repeatedly before menacing the Teen Titans and reached an all-time low when he was trounced by Little Boy Blue and the Blue Boys. It was revealed after raping Sue Dibny, Zatanna, under League orders, lobotomized the villain. During the events of Identity Crisis, Light's memory was restored and he took Black Adam's seat on the Society.Sonar Green Lantern #14 (July 1962) Primarily a Green Lantern foe, Sonar became a global threat when he laid claim to the Soviet Union leading an army of brainwashed metahumans, such as the Global Guardians, the Royal Flush Gang, Eurocrime and Justice League Antarctica, against Justice League Europe, the Justice Society and a small army of allies.Zedd Brann Justice League of America #13 (August 1962) An alien from the planet Skarn who uses a device that will drain the life force of the universe. Brann also employs a device that makes perfect robot duplicates of his enemies to use against his foes.Maestro Justice League of America #16 (Decem