William Jefferson may refer to:
William Jefferson (actor) (1876–1946), American stage and film actor William J. Jefferson (born 1947), former Louisiana Democratic congressman Will Jefferson (born 1979), English cricketer William Jefferson (United Nations employee) (1951–1995), killed serving in Bosnia in the 1990s Bill Jefferson (baseball) (1904–1976), American baseball pitcher
See also William Jefferson Clinton, full name of former U.S. President Bill Clinton (born 1946)