CPK may refer to:
Businesses and organizations California Pizza Kitchen, a restaurant chain Chesapeake Utilities (New York Stock Exchange symbol CPK) Communist Party of Kampuchea, commonly known as the Khmer Rouge Communist Party of Korea, a former political party in Korea Communist Party of Kenya, a Kenyan political party
Science and technology Process capability index (Cpk), a measure of process capability CPK coloring, a way to color atoms when visualizing molecular models Creatine phosphokinase, an enzyme found in humans, or alternatively a blood test for it
Transport Carpenders Park railway station, England (National Rail station code CPK) Central Communication Port (Polish: Centralny Port Komunikacyjny), a planned airport in Poland
Other uses "C.P.K." (Unwritten Law song) Cabbage Patch Kids, a line of children's dolls