Spark of Life may refer to:
"Spark of Life" (CSI), a fifth-season episode of the American crime drama CSI: Crime Scene Investigation Spark of Life (novel), a 1952 novel by Erich Maria Remarque "That Spark of Life", a 1943 novel by Pavel Bazhov Spark of Life (album), a 2014 album by Marcin Wasilewski Vitalism, the belief in a "vital spark" of life