DeJarnette is a surname. Notable people with the surname include:
Daniel Coleman DeJarnette Sr. (1822–1881), prominent Virginia politician David L. DeJarnette (1907–1991), archaeologist Edmund DeJarnette (1897–1966), Member of the Virginia House of Delegates Edmund DeJarnette (1938–2015), ambassador Evelyn Magruder DeJarnette (1842–1902), American author Joseph DeJarnette (1866–1957), the director of Western State Hospital (located in Staunton, Virginia) from 1905 to 1943 Layron DeJarnette (fl. 2000s–2010s), illustrator
See also DeJarnette's Tavern, nationally registered historic place near Nathalie, Halifax County, Virginia, USA DeJarnette, Virginia, unincorporated community in Caroline County, in the U.S. state of Virginia