Notable persons with the last name Poffenbarger include:
George Poffenbarger (1861–1951), justice of the West Virginia Supreme Court Livia Simpson Poffenbarger (1862–1937), newspaper editor/owner, historian, social and political activist and wife of George Poffenbarger Saylor Poffenbarger (born 2003), American basketball player
Notable persons with variants of the name: Albert Poffenberger (1885–1977), American psychologist Boots Poffenberger (1915–1999), American baseball pitcher Virginia Poffenberger (1934–2013), American politician from Iowa
See also Poffenberger Road Bridge, in Maryland, United States