Leffingwell may refer to:

People Albert Leffingwell (physician) (1845–1916), physician and reformer Albert Leffingwell (novelist) (1895–1946), American novelist Charles Wesley Leffingwell (1840–1928), American author, educator, and Episcopal priest Douglas Leffingwell (1826–1900), American politician from Iowa Edward Leffingwell (1941–2014), American art critic and curator Ernest de Koven Leffingwell (1875–1971) arctic explorer, geologist Frank Seth Leffingwell (1868–1945), American and Canadian politician Lee Leffingwell (born 1939), American politician from Texas Russell Cornell Leffingwell (1878–1960), American banker William Leffingwell (Iowa politician) (1822–1884), American politician from Iowa William Leffingwell (New York politician) (1855–1927), American politician from New York state William Henry Leffingwell (1876–1934), American management author

Places Leffingwell Camp Site Leffingwell Inn Leffingwell Township, Ashtabula County, Ohio, renamed Orwell Township