5E or 5-E can refer to:
5°E, or 5th meridian east, a longitude coordinate 5e, a type of Category 5 cable 5E, a learning cycle developed by Biological Sciences Curriculum Study. 5E (album), a 2018 album by N.O.R.E. Astra 5°E, a communications satellite Dungeons & Dragons 5th edition, a fantasy tabletop role-playing game (RPG) released in 2014. F-5E, a model of Northrop F-5 jet Five Eyes, an espionage alliance between the US, UK, NZ, Canada, and Australia. Tropical Depression Five-E (2008) SGA Airlines (IATA airline code)
See also E5 (disambiguation)