Lesson No.1 or Lesson 1 or Lesson One may refer to:

Lesson 1, a music mix by Double Dee and Steinski Lesson 1, a 2013 album by E-girls Lesson 1 (Red Warriors album), 1986 Lesson One: Misanthropy!, an album by Death in June Lesson No. 1, a 1980 Glenn Branca EP Lesson No.1, a 2006 sampler album by Imperial Recordings "Lesson One", a 1962 single by Russ Conway "Lesson No.1", a song by Viva Voce from The Heat Can Melt Your Brain "Lesson #1", a song by Anthony Rapp from Look Around