Despaigne is a Cuban surname. People with this name include:
Alfredo Despaigne, Cuban baseball player Joël Despaigne, Cuban volleyball player Lázaro Martínez Despaigne, Cuban sprinter Oreidis Despaigne, Cuban judoka Odrisamer Despaigne, Cuban baseball player Rolando Jurquin Despaigne, Cuban volleyball player Victoria Despaigne, Cuban heptathlete Yordanis Despaigne, Cuban boxer Yosvany Despaigne, Cuban judoka
See also Despain Jean D'Espagnet