Alexopoulos () is a Greek patronymic surname meaning "son of Alexios". The female form of the surname is Alexopoulou (Αλεξοπούλου). Notable people with the surname include:
Alexopoulos Alexios Alexopoulos (born 1971), Greek sprinter Athina-Theodora Alexopoulou (born 1983), Greek sprint canoeist Constantine John Alexopoulos (1907–1986), Greek-American mycologist Georgios Alexopoulos (born 1977), Greek footballer Heléne Alexopoulos, American ballet dancer
Alexopoulou
Athina-Theodora Alexopoulou (born 1983), Greek sprint canoer Christina Alexopoulou (born 1978), Greek politician Kleoniki Alexopoulou (born 1984), Greek historian