Union Avenue United Methodist Church was a historic church building in Memphis, Tennessee, that is listed on the National Register of Historic Places under the name Union Avenue Methodist Episcopal Church, South. The building was located on a street corner at 2117 Union Avenue.

The building was no longer in use as a church when it was sold in February 2011 to CVS Pharmacy. The company paid $2.25 million for the church property and also paid $650,000 to buy an adjoining property from a different owner.CVS completes purchase of Union Avenue church, Memphis Business Journal, February 18, 2011CVS/Pharmacy Buys Former Union Ave. United Methodist Land, February 21, 2011 Demolition of the structure began in March 2011.Sanctuary Wall of Midtown Church Demolished, [WMC], March 29, 2011

Members of the family that sold the land for church use in 1912 attempted to block the sale to CVS on the basis of a restrictive covenant in the deed that required the property to be used as a "place of divine worship."

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