Patuxent may refer to:
People Patuxent people, an Algonquian people indigenous to what is now the Mid-Atlantic United States
Places and geological features Patuxent, Maryland, an unincorporated community in Charles County Patuxent Ice Stream, between the Patuxent Range and Pecora Escarpment Patuxent Range, a mountain chain in Antarctica Patuxent River, Maryland Patuxent Wildlife Research Center, a U.S. Fish and Wildlife Service facility in Beltsville, Maryland Naval Air Station Patuxent River, an installation of the United States Navy in St. Mary's County, Maryland Calvert County, Maryland, once known as Patuxent County Woodwardville, Maryland, an unincorporated community known as Patuxent from 1927 to the 1980s
Other Patuxent River stone, the state gem of Maryland , sea-going tugboat in commission with the United States Navy from 1909 to 1924 , an oiler in commission with the United States Navy from 1942 to 1946 , a fleet replenishment oiler in service with the United States Navy since 1995.