Frank Horton may refer to:
Frank Horton (New York politician) (1919–2004), United States Representative from New York Frank Horton (physicist) (1878–1957), British physicist Frank E. Horton (born 1939), American educator and administrator Frank L. Horton (1918–2004), American antiques dealer and museum director Frank O. Horton (1882–1948), United States Representative from Wyoming Frank Reed Horton (1896–1966), United States educator