Vogelstein is a surname. Notable people with the surname include:
Bert Vogelstein (born 1949), an American Howard Hughes Medical Institute investigator at The Johns Hopkins University Carl Christian Vogel von Vogelstein (1788–1868), German painter Rabbi Heinemann Vogelstein (1841–1911), German liberal rabbi Rabbi (1870–1942), German-American historian, liberal rabbi Ludwig Vogelstein (1871–1934), German-American industrialist and philanthropist (1880–1957), banker and industrialist Julie Braun-Vogelstein (1883–1971), German-American art historian, author, editor, and journalist