Bonsignore is a surname. Notable people with the surname include:
Ferdinando Bonsignore (1760–1843), Italian architect and designer Gregory Bonsignore (born 1983), American playwright and screenwriter Jason Bonsignore (born 1976) American hockey player Justin Bonsignore (born 1988), American racing driver Lillian Bonsignore, former head of the EMS bureau of the New York City Fire Department Michael Bonsignore (born 1941), American business executive Vito Bonsignore (born 1943), Italian politician