John McLoughlin (1784–1857) was a Canadian fur trader and Oregon pioneer.
John McLoughlin may also refer to: John McLoughlin (Proctor), a 1953 bronze sculpture of John McLoughlin by Alexander Phimister Proctor John McLoughlin (police officer) (born c. 1953), 9/11 attacks survivor John McLoughlin Jr. (1812–1842), Metis Chief Trader employed by the Hudson's Bay Company John McLaughlin (performance artist) (1956–1990), New York City performance artist, singer, and parodist, known as John Sex
See also John McLoughlin Bridge (built in 1933) in Oregon, US John McLoughlin House (built in 1845) in Oregon, US John McLaughlin (disambiguation) John MacLoughlin (1871–1943), Irish politician John MacLaughlin (disambiguation) John Loughlin (disambiguation)