William Pilkington may refer to:
Liam Pilkington (1894–1977), also known as William or Billy, served in the Irish Republican Army during the Irish War of Independence William Pilkington (architect) (1758–1848), English architect William Pilkington (cricketer) (1806–1832), English cricketer William Pilkington (rugby union) (1870–1935), English rugby union player Harry Pilkington (William Henry Pilkington, 1905–1983), glass manufacturer Sir William Pilkington, 8th Baronet (1775–1850), of the Pilkington baronets Sir William Milborne-Swinnerton-Pilkington, 10th Baronet (1831–1855), of the Pilkington baronets