Marat Safin defeated Juan Carlos Ferrero in the final, 6–3, 6–3, 6–4 to win the singles tennis title at the 2000 Barcelona Open.
Félix Mantilla was the defending champion, but lost in the second round to Nicolás Lapentti.
In the first round, wildcard entrant Sergi Bruguera defeated future world No. 1 Roger Federer 6–1, 6–1. This was Federer's worst loss, by number of games won, in his entire career.
Seeds A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. The top eight seeds received a bye to the second round.
Draw
Qualifying Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
References