M80 or M-80 may refer to:
Military BVP M-80, a Yugoslav military vehicle M80, a U.S. military type of the 7.62×51mm NATO rifle cartridge M80, training version of the M19 mine M80 Stiletto, a 2006 prototype naval vessel M80 Zolja, a Yugoslav anti-tank rocket launcher Zastava M80, an assault rifle
Transportation M-80 (Michigan highway), a state highway in the Upper Peninsula of Michigan M80 motorway, a motorway in Scotland M80 Ring Road (aka Western Ring Road and Metropolitan Ring Road), a freeway in Melbourne, Australia
Other uses M-80 (band), an American punk band M-80 (explosive), a large firecracker M80 Radio, a radio station from Portugal and Spain Monster M-80, a tropical juice energy drink M 80, an age group for Masters athletics (athletes aged 35+) M80/2, the vehicle used on the M-Bahn in Berlin, Germany Messier 80, a globular cluster in the constellation Scorpius Microsoft MACRO-80, a macro assembler M-80, a minor Hydra-affiliated character in Marvel Comics
See also Model 80 (disambiguation) Matey (disambiguation) Mighty (disambiguation)