De Filippi is an Italian surname. Notable people with the surname include:

Andrea De Filippi (born 2000), known professionally as Alfa, Italian singer-songwriter and rapper Filippo De Filippi (1814–1867), Italian zoologist and physician Filippo De Filippi (explorer) (1869–1938), Italian explorer and physician Maria De Filippi (born 1961), Italian television host José María De Filippi (born 1982), Argentine footballer Ludovico De Filippi (1872–1918), Italian naval officer

See also De Filippo, a surname