Mouzinho is a surname. Notable people with the surname include:
João Mouzinho de Albuquerque (1797–1881), Portuguese writer and administrator João Pedro Mouzinho de Albuquerque (1736–1802), Portuguese nobleman Joaquim Augusto Mouzinho de Albuquerque (1855–1902), Portuguese soldier José Mouzinho (born 1885), Portuguese horse rider Cidália Lopes Nobre Mouzinho Guterres, first lady of East Timor Luís da Silva Mouzinho de Albuquerque (1792–1846), Portuguese military officer, engineer, poet, scientist and politician Mouzinho (footballer) (born 2002), East Timorese footballer
See also , a steamship which in 1930 was renamed Mouzinho