The Charleston Southern Railway was a South Carolina railroad established in the early part of the 20th century.

The Charleston Southern Railway, incorporated by the South Carolina General Assembly in 1915,Wikipedia, WikiProject Trains, ICC valuations, Seaboard Air Line was to be an extension of the Seaboard Air Line Railroad, with an 85-mile route from Charleston, South Carolina, to Savannah, Georgia, planned.Engineering and Contracting, Volume 64, 1915, page 475

The Charleston Southern merged with the Carolina, Atlantic and Western Railway in September 1915.Virginia State Corporation Commission, Annual Report, 1917, page 314

Two months later, the Carolina, Atlantic and Western changed its name to the Seaboard Air Line Railroad.Virginia State Corporation Commission, Annual Report, 1917, page 314

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