53rd Street may refer to:
53rd Street (Manhattan), a midtown cross street in New York City
New York City Subway 53rd Street (BMT Fourth Avenue Line), in Brooklyn; serving the trains Fifth Avenue / 53rd Street (IND Queens Boulevard Line), in Manhattan; serving the trains Lexington Avenue – 53rd Street (IND Queens Boulevard Line), also in Manhattan; serving the trains 53rd Street (IRT Third Avenue Line), a defunct aboveground station in Manhattan, closed 1955
Elsewhere 51st/53rd Street/Hyde Park station, a commuter train station in Chicago