De Cesare or DeCesare is a surname. Notable people with the surname include:
People with the surname De Cesare Nicolò De Cesare (born 1990), Italian footballer Ciro De Cesare (born 1971), Italian footballer John De Cesare (1890–1972), American sculptor
People with the surname DeCesare Carmella DeCesare (born 1982), American model Donald H. DeCesare (1924–2010), American politician Michele DeCesare, actress, daughter of David Chase
See also Di Cesare, a name Cesare, a name