Sheldon Farmhouse is a historic home located at Duanesburg in Schenectady County, New York. It was built about 1795 and is a two-story, five-bay, frame residence on a limestone foundation in a vernacular Federal style. It features a gable roof and interior end chimneys. Also on the property are two contributing barns. ()

The property was covered in a 1984 study of Duanesburg historical resources. () It was listed on the National Register of Historic Places in 1984.

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