Makdisi is a surname. Notable people with the surname include:
George Makdisi (1920–2002), American professor of oriental studies Jean Said Makdisi (born 1940), Palestinian writer and scholar Saree Makdisi (born 1964), American literary critic and professor, son of the above Ussama Makdisi (born 1968), Palestinian American historian, son of Jean Said Makdisi above. Karim Makdisi, professor at Tufts, also son of Jean Said Makdisi. John Makdisi, American law professor
See also Wadad Makdisi Cortas (1909–1979), Lebanese-Palestinian educator and memoirist