Frank Simpson may refer to:
Frank F. Simpson (1868–1948), American physician from Pennsylvania Frank W. Simpson (1872–1929), American college football coach Frank B. Simpson (1883–1966), American architect Frank Simpson (British Army officer) (1899–1986), British Army General Frank Simpson (cricketer) (1909–1992), British Army officer and cricketer Frank Simpson (politician) (born 1945), American politician in the Oklahoma Senate Nuke (Marvel Comics), real name: Frank Simpson, a supervillain from Marvel Comics