James Gresham may refer to:
James Gresham (poet), 17th-century English poet James Gresham (MP), 17th-century English Member of Parliament for Haslemere James Gresham (footballer), English footballer active in the 1890s James Bethel Gresham (1893–1917), American serviceman killed in World War I Jimmy Gresham (born 1934), singer and writer
See also James Gresham Barrett, American politician