WIS (acronym) may stand for:
Radio and television WIS (TV), a television station (channel 10) licensed to serve Columbia, South Carolina WVOC, a radio station in Columbia, South Carolina which held the call sign WIS from 1930–86
Schools Walsh Intermediate School, a middle school in Connecticut, the United States Washington International School, in the District of Columbia, United States Weizmann Institute of Science, in Rehovot, Israel West Island School, a British high school in Hong Kong, China Windhoek International School, in Windhoek, Namibia Wellington International School, in Dubai, the United Arab Emirates
Other Outer Hebrides (Western Isles), Scotland, Chapman code WIS Wisconsin, a U.S. state wisit, web-based integrating systems information technology Wedge imaging spectrometer, a type of imaging spectrometer WiS, the original name of the Vis pistol Book of Wisdom, one of the deuterocanonical books of the Bible Working Income Supplement, a former tax benefit administrated by the Government of Canada