Clephane is a surname. Notable people with the surname include:
Elizabeth C. Clephane (1830–1869), Scottish hymn writer James O. Clephane (1842–1910), American court reporter and venture capitalist James Clephane-Cameron (1985-), English poet John Clephane (died 1758), Scottish physician Neil Clephane-Cameron (1960-), English historian
See also Clephane-Cameron, a surname