Degener is a German surname. Notable people with the surname include:
Edward Degener (1809–1890), German-American politician Gülşen Degener (born 1968), Turkish-born German carom billiards player Jeannette Schmidt Degener (1926–2017), Nigerien politician Isa Degener (1924–2018), German-American botanist and conservationist Joachim Degener (1883–1953), German general Johannes Degener (1889–1959), German politician Otto Degener (1899–1988), American botanist and conservationist Richard Degener (1912–1995), American diver Theresia Degener (born 1961), German jurist and professor of law
See also Degen (surname) Degner