2nd Duke of Buckingham may refer to:
Edmund Sheffield, 2nd Duke of Buckingham and Normanby (1716–1735), English nobleman George Villiers, 2nd Duke of Buckingham (1628–1687), English statesman Henry Stafford, 2nd Duke of Buckingham (1455–1483), Knight of the Garter Richard Temple-Grenville, 2nd Duke of Buckingham and Chandos (1797–1861), British politician