Seoane is a toponymic surname of Galician origin, meaning "Saint John". Notable people with the name include:
Antonio Vega de Seoane (1887–1947), Spanish engineer, businessman and politician Consuelo Seoane (1876–1964), American military officer Diego Seoane (Spanish footballer) (born 1988), Spanish footballer Diego Seoane (Uruguayan footballer) (born 1976), Uruguayan footballer Edgardo Seoane (1903–1978), Peruvian engineer, agronomist and politician Enrique Seoane Ros (1915–1980), Peruvian architect Fernando Seoane (born 1983), Spanish footballer Gerardo Seoane (born 1978), Swiss footballer Iván Martín Seoane (born 1987), Spanish swimmer and coach Jaime Seoane (born 1997), Spanish footballer José María Seoane (1913–1989), Spanish actor Kenia Seoane Lopez (born 1974), American lawyer and judge Luís Seoane (1910–1979), Argentine-Spanish lithographer and artist Manny Seoane (born 1955), American baseball player Manuel Seoane (1902–1975), Argentine footballer Manuel Burga Seoane (born 1957), Peruvian lawyer and football administrator Manuel Velarde Seoane (1833–1900), Peruvian military general and politician María Seoane (1948–2023), Argentine journalist, writer, and film director Mariana Seoane (born 1976), Mexican actress, model and singer Sito Seoane (born 1989), American soccer player Toni Seoane (born 1989), Spanish footballer