Briffa is a surname. Notable people with the surname include:
Emmanuel Briffa (1875–1955), Canadian theatre decorator Jimmy Briffa (born 1948), Maltese professional footballer and manager Keith Briffa (1952–2017), climatologist in the Climatic Research Unit at the University of East Anglia Louis Briffa (born 1971), Maltese poet Roderick Briffa (born 1981), Maltese professional footballer Rużar Briffa (1906–1963), Maltese poet, dermatologist, major figure in Maltese literature Tony Briffa (politician) (born 1971 Antoinette Briffa), Australian mayor, intersex activist and educator Tony Briffa (artist) (born 1959), Maltese artist
See also Biffa Braffais Briffons Brouffia