Darion is a masculine name; variants include Darian and Darien. Notable people with the name include:

Given name Darion Atkins (born 1992), American professional basketball player Darion Anderson (born 1987), American basketball player Darion Clark (born 1994), American football player Darion Conner (born 1967), American football player convicted of vehicular homicide Darion Copeland (born 1993), American soccer player

Surname Joe Darion (1917–2001), American musical theater lyricist