Manuel Vargas may refer to:
Manuel Vargas Acuña (), Chilean politician Manuel Vargas (boxer) (born 1981), Mexican professional boxer Manuel Vargas (footballer) (born 1991), Panamanian footballer Manuel Vargas (singer), lead member of the Mariachi Sangre Mexicana Manuel Francisco de Vargas (1849–1921), Portuguese engineer and politician Manuel Sarmanho Vargas (1917–1997), Brazilian politician
See also